Segatroxaban | FIIa/Xa inhibitor | Probechem Biochemicals

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Chemical Structure : Segatroxaban

Segatroxaban (SAR107375E)

Catalog No.: PC-24866Not For Human Use, Lab Use Only.

Segatroxaban (SAR107375E) is a potent and highly selective dual FIIa/Xa inhibitor with Ki values of 8 nM and 1 nM on FIIa and FXa, IC50 values of 0.3/0.7 nM (FIIa/FXa) in buffer and of 16/3 nM (FIIa/FXa) in plasma, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	568.10
Formula	C24H30ClN5O5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Thiophenecarboxamide, 5-chloro-N-[(2S)-2-[[[2-methyl-3-(2-oxo-1-pyrrolidinyl)phenyl]sulfonyl]amino]-3-(4-methyl-1-piperazinyl)-3-oxopropyl]-

References

1. Beck H, et al. J Med Chem. 2025 Jun 11. doi: 10.1021/acs.jmedchem.5c00538.

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Segatroxaban (SAR107375E)

Biological Activity

Physicochemical Properties

References

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