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Chemical Structure : Selexipag
CAS No.: 475086-01-2
Catalog No.: PC-20915Not For Human Use, Lab Use Only.
Selexipag (NS-304) is an orally available, long-acting nonprostanoid prostacyclin receptor (IP receptor) agonist, the prodrug of the active form of MRE-269.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 1 g | Get quote |
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Selexipag (NS-304) is an orally available, long-acting nonprostanoid prostacyclin receptor (IP receptor) agonist, the prodrug of the active form of MRE-269.
MRE-269 inhibits the human IP receptor with inhibition constant (Ki) of 20 nM.
Selexipag (NS-304) inhibits the binding of [3H]Iloprost to the human and rat IP receptors in a concentration-dependent manner., with Ki of 260 nM for the human IP receptor and 2100 nM for the rat IP receptor.
Selexipag (NS-304) increases intracellular cAMP levels in hIP-CHO cells with EC50 of 177 nM.
Selexipag (NS-304) is a promising drug candidate for various vascular diseases, especially pulmonary arterial hypertension and arteriosclerosis obliterans.
| M.Wt | 496.63 | |
| Formula | C26H32N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide |
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1. Morrison K, et al. J Pharmacol Exp Ther. 2010 Oct;335(1):249-55.
2. Kuwano K, et al. J Pharmacol Exp Ther. 2008 Sep;326(3):691-9.
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