Selicrelumab
(Anti-human CD40 mAb, human IgG2-Kappa; RO 7009789; RG 7876)
Catalog No.: PC-Ab1039Not For Human Use, Lab Use Only.
Selicrelumab (RO 7009789) is a fully humanized monoclonal IgG2 antibody that binds CD40 with a very high affinity (Kd=0.4 nM). Selicrelumab does not bind the same site as natural CD40L and hence does not block the natural CD40L-CD40 interaction. Selicrelumab binds to CD40 on a variety of immune cell types. This triggers the cellular proliferation and activation of antigen-presenting cells (APCs), and activates B-cells and T-cells, resulting in an enhanced immune response. Selicrelumab also binds
Selicrelumab (RO 7009789) is a fully humanized monoclonal IgG2 antibody that binds CD40 with a very high affinity (Kd=0.4 nM). Selicrelumab does not bind the same site as natural CD40L and hence does not block the natural CD40L-CD40 interaction. Selicrelumab binds to CD40 on a variety of immune cell types. This triggers the cellular proliferation and activation of antigen-presenting cells (APCs), and activates B-cells and T-cells, resulting in an enhanced immune response. Selicrelumab also binds to and activates CD40 present on the surfaces of some solid tumor cells, leading to apoptosis and decreased tumor growth.
Physicochemical Properties
M.Wt
Formula
Human IgG2-Kappa
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
PBS, pH 7.0
Contains no stabilizers or preservatives
