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Selonsertib

Chemical Structure : Selonsertib

CAS No.: 1448428-04-3

Selonsertib (GS-4997;GS4997;GS 4997)

Catalog No.: PC-45565Not For Human Use, Lab Use Only.

Selonsertib (GS-4997) is a highly selective and potent, ATP-competetive inhibitor of ASK1 (Apoptosis Signal-regulating Kinase 1, MAP3K5) with pIC50 of 8.3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Selonsertib (GS-4997) is a highly selective and potent, ATP-competetive inhibitor of ASK1 (Apoptosis Signal-regulating Kinase 1, MAP3K5) with pIC50 of 8.3.
Selonsertib (GS-4997) antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells.
Selonsertib (GS-4997) with potential anti-inflammatory, antineoplastic and anti-fibrotic activities; orally bioavailable.

Physicochemical Properties

M.Wt 445.4921
Formula C24H24FN7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

Benzamide, 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-

References

1. Lin JH, et al. Nephron. 2015;129(1):29-33.
2. Ji N, et al. Cancer Lett. 2019 Jan;440-441:82-93.

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