Chemical Structure : Selovoxolone
CAS No.:
1786406-66-3
Selovoxolone
(CKBA)
Catalog No.: PC-27498Not For Human Use, Lab Use Only.
CKBA (Selovoxolone) is a small molecule inhibitor of Th17 cell differentiation, inhibits mouse and human Th17 cell differentiation with an IC50 of 3.28 and 3.61 μM, respectively, and directly targeted acetyl-CoA carboxylase 1 (ACC1), inhibits ACC1 activity in vitro with IC50 of 5.02 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CKBA (Selovoxolone) is a small molecule inhibitor of Th17 cell differentiation, inhibits mouse and human Th17 cell differentiation with an IC50 of 3.28 and 3.61 μM, respectively, and directly targeted acetyl-CoA carboxylase 1 (ACC1), inhibits ACC1 activity in vitro with IC50 of 5.02 uM.
CKBA potently inhibits Th17 cell differentiation through blocking ACC1-mediated fatty acid synthesis.
CKBA inhibits fatty acid synthesis in HepG2 cells with IC50 of 0.28 uM.
CKBA ointment improves psoriasis-like skin inflammation in mice.
Physicochemical Properties
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M.Wt
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580.85
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Formula
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C37H56O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3α,4β)-3-[(Cyclohexylcarbonyl)oxy]-11-oxours-12-en-23-oic acid
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References
1. Patent CN119970750 A 2025-05-13.
2. Fangzhou Lou, et al. Br J Pharmacol. 2024 Apr;181(8):1290-1307.
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