Catalog No.: PC-60209Not For Human Use, Lab Use Only.
Selpercatinib (LOXO-292, LOXO292) is a potent, selective, orally available RET kinase inhibitor with IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively.
Selpercatinib (LOXO-292, LOXO292) is a potent, selective, orally available RET kinase inhibitor with IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively.
LOXO-292 displays >100-fold selectivity versus important off-targets.
LOXO-292 shows anti-tumor activty in the brain and periphery in RET-dependent tumor models in vivo.
