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Chemical Structure : Selurampanel
CAS No.: 912574-69-7
Catalog No.: PC-61712Not For Human Use, Lab Use Only.
Selurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM.
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|---|---|---|---|
| 5 mg | $328 | In stock | |
| 10 mg | $528 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Selurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM.
Selurampanel (BGG 492) displays >100-fold selectivity over NMDA and kainate receptors.
Selurampanel (BGG 492) demonstrates excellent oral potency against MES-induced generalized tonic-clonic seizures in rodents as well as significant activity in patients suffering from various forms of epilepsy.
| M.Wt | 377.418 | |
| Formula | C16H19N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(7-isopropyl-6-(1-methyl-1H-pyrazol-5-yl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)methanesulfonamide |
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1. Orain D, et al. ChemMedChem. 2017 Feb 3;12(3):197-201.
2. Kasteleijn-Nolst Trenité D, et al. Epilepsia. 2015 Jun;56(6):924-32.
3. Faught E. Expert Opin Investig Drugs. 2014 Jan;23(1):107-13.
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