Catalog No.: PC-73177Not For Human Use, Lab Use Only.
Semaglutide (NN 9535) is a glucagon-like peptide-1 (GLP-1) peptide agonist with binding IC50 of 0.38 nM, increases insulin secretion and sugar metabolism.
Semaglutide (NN 9535) is a glucagon-like peptide-1 (GLP-1) peptide agonist with binding IC50 of 0.38 nM, increases insulin secretion and sugar metabolism.
Semaglutide also appears to enhance growth of β cells in the pancreas, which are the sites of insulin production.
Semaglutide inhibits glucagon, which is a hormone that increases blood sugar.
Semaglutide reduces food intake by lowering appetite and slows down digestion.
Semaglutide is a polypeptide that contains a linear sequence of 31 amino acids joined together by peptide linkages.
Amino acid sequence: HXEGTFTSDV SSYLEGQAAK EFIAWLVRGR G.
Physicochemical Properties
M.Wt
4113.64
Formula
C187H291N45O59
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Amino acid sequence: HXEGTFTSDV SSYLEGQAAK EFIAWLVRGR G.
References
1. Kapitza C, et al. J Clin Pharmacol. 2015 May;55(5):497-504.
2. Monami M, et al. Exp Diabetes Res. 2012;2012:672658.
3. Gotfredsen CF, et al. Diabetes. 2014 Jul;63(7):2486-97.
4. Lau J, et al. J Med Chem. 2015 Sep 24;58(18):7370-80.
