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Senaparib

Chemical Structure : Senaparib

CAS No.: 1401682-78-7

Senaparib (IMP4297)

Catalog No.: PC-38373Not For Human Use, Lab Use Only.

Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with IC50 of 6.27 nM/1.57 nM, respectively, exhibits strong antitumor activity.

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Biological Activity

Senaparib (IMP4297) is a novel highly potent and selective, oral PARP1/2 inhibitor with IC50 of 6.27 nM/1.57 nM, respectively, exhibits strong antitumor activity.
Senaparib (IMP4297) has demonstrated 20-fold more potent than olaparib in vivo and showing strong antitumor activity in preclinical studies, IMP4297 is well-tolerated with significant anti-tumor activity in clinical investigations.

Physicochemical Properties

M.Wt 478.460
Formula C24H20F2N6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-fluoro-1-(4-fluoro-3-(4-(pyrimidin-2-yl)piperazine-1-carbonyl)benzyl)quinazoline-2,4(1H,3H)-dione

References

1. Junning Cao, et al. 2019 ASCO Annual Meeting I.

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