Chemical Structure : Senaparib
CAS No.: 1401682-78-7
Catalog No.: PC-38373Not For Human Use, Lab Use Only.
Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with IC50 of 6.27 nM/1.57 nM, respectively, exhibits strong antitumor activity.
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Senaparib (IMP4297) is a novel highly potent and selective, oral PARP1/2 inhibitor with IC50 of 6.27 nM/1.57 nM, respectively, exhibits strong antitumor activity.
Senaparib (IMP4297) has demonstrated 20-fold more potent than olaparib in vivo and showing strong antitumor activity in preclinical studies, IMP4297 is well-tolerated with significant anti-tumor activity in clinical investigations.
M.Wt | 478.460 | |
Formula | C24H20F2N6O3 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
5-fluoro-1-(4-fluoro-3-(4-(pyrimidin-2-yl)piperazine-1-carbonyl)benzyl)quinazoline-2,4(1H,3H)-dione |
1. Junning Cao, et al. 2019 ASCO Annual Meeting I.
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