Catalog No.: PC-23531Not For Human Use, Lab Use Only.
Seratrodast (AA2414) is a potent, specific thromboxane A2 (TXA2) receptor antagonist, competitively inhibits the contractile response to U-46619 in guinea pig tracheal and parenchymal strips and dog saphenous vein strips with pA2 values of 7.69, 8.29 and 6.79, respectively, also inhibits ferroptosis.
Seratrodast (AA2414) is a potent, specific thromboxane A2 (TXA2) receptor antagonist, competitively inhibits the contractile response to U-46619 in guinea pig tracheal and parenchymal strips and dog saphenous vein strips with pA2 values of 7.69, 8.29 and 6.79, respectively, also inhibits ferroptosis. Seratrodast (AA2414) inhibits the contractile responses of guinea pig tracheal strip to PGD2, 9 alpha, 11 beta-PGF2 and PGF2 alpha with pA2 values of 7.20, 7.79 and 5.71, respectively. Seratrodast (AA2414) inhibits ferroptosis by suppressing lipid peroxidation. Seratrodast (AA2414) reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. Seratrodast (AA2414) suppresses ferroptosis, but not apoptosis and necroptosis. Seratrodast (AA2414) ameliorates the severity of renal ischemia-reperfusion injury in mice.
