Chemical Structure : Sevabertinib
CAS No.:
2521285-05-0
Sevabertinib
(BAY 2927088, BAY2927088)
Catalog No. : PC-25021Not For Human Use, Lab Use Only.
Sevabertinib (BAY 2927088) is a potent, selective, reversible inhibitor of mutant epidermal growth factor receptors 2 (HER2), including HER2 exon 20 insertions and HER2 point mutations.
Packing Price Stock Quantity 5 mg $78 In stock 0 1 2 3 4 5 10 mg $118 In stock 0 1 2 3 4 5 25 mg $198 In stock 0 1 2 3 4 5 50 mg $348 In stock 0 1 2 3 4 5 100 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-2502101
Biological Activity
Sevabertinib (BAY 2927088) is a potent, selective, reversible inhibitor of mutant epidermal growth factor receptors 2 (HER2), including HER2 exon 20 insertions and HER2 point mutations.
Physicochemical Properties
M.Wt
484.94
Formula
C24H25ClN4O5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(S)-2-(3-((1,4-Dioxan-2-yl)methoxy)pyridin-4-yl)-3-((3-chloro-2-methoxyphenyl)amino)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
References
1. Franziska Siegel, et al. Cancer Res (2025) 85 (8_Supplement_1): 5610.
2. Patent WO2020216781 A1.
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