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Chemical Structure : Sigma1-IN-4
Catalog No.: PC-62827Not For Human Use, Lab Use Only.
Sigma1-IN-4 is a novel small molecule sigma-1 receptor inhibitor with Ki of 38 nM.
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Sigma1-IN-4 is a novel small molecule sigma-1 receptor inhibitor with Ki of 38 nM.
Sigma1-IN-4 has weak hERG inhibition (IC50>400 nM) and good in vitro ADME.
Sigma1-IN-4 is a useful tool compound for use in future studies to validate sigma for in vivo efficacy in mouse models of CRPC.
| M.Wt | 321.78 | |
| Formula | C16H17ClFN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Salvino JM, et al. Bioorg Med Chem Lett. 2017 May 15;27(10):2216-2220.
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