Silvestrol | eIF4A inhibitor | Probechem Biochemicals

Chemical Structure : Silvestrol

Silvestrol ((-)-Silvestrol)

Catalog No.: PC-43430Not For Human Use, Lab Use Only.

Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, and specific eukaryotic translation initiation factor 4A (eIF4A) inhibitor.

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Biological Activity

Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, and specific eukaryotic translation initiation factor 4A (eIF4A) inhibitor.
Silvestrol induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway.
Silvestrol effectively targets the cyclin/CDK/Rb pathway, and additionally induces cytotoxicity via intrinsic apoptosis, exhibits low nanomolar potency both in MCL cell lines and primary MCL tumor cells.
Silvestrol demonstrates B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo.

Physicochemical Properties

M.Wt	654.66
Formula	C34H38O13
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO; H2O: < 1 mg/mL
Chemical Name/SMILES	1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 6-[[(2S,3R,6R)-6-[(1R)-1,2-dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3aR,8bS)-

References

1. Lucas DM, et al. Blood. 2009 May 7;113(19):4656-66.

2. Kim S, et al. Anticancer Res. 2007 Jul-Aug;27(4B):2175-83.

3. Hwang BY, et al. J Org Chem. 2004 May 14;69(10):3350-8.

4. Alinari L, et al. Clin Cancer Res. 2012 Sep 1;18(17):4600-11.

Silvestrol ((-)-Silvestrol)

Biological Activity

Physicochemical Properties

References

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