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Chemical Structure : Silvestrol
Catalog No.: PC-43430Not For Human Use, Lab Use Only.
Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, and specific eukaryotic translation initiation factor 4A (eIF4A) inhibitor.
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Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, and specific eukaryotic translation initiation factor 4A (eIF4A) inhibitor.
Silvestrol induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway.
Silvestrol effectively targets the cyclin/CDK/Rb pathway, and additionally induces cytotoxicity via intrinsic apoptosis, exhibits low nanomolar potency both in MCL cell lines and primary MCL tumor cells.
Silvestrol demonstrates B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo.
| M.Wt | 654.66 | |
| Formula | C34H38O13 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO; H2O: < 1 mg/mL |
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1. Lucas DM, et al. Blood. 2009 May 7;113(19):4656-66.
2. Kim S, et al. Anticancer Res. 2007 Jul-Aug;27(4B):2175-83.
3. Hwang BY, et al. J Org Chem. 2004 May 14;69(10):3350-8.
4. Alinari L, et al. Clin Cancer Res. 2012 Sep 1;18(17):4600-11.
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