Simeprevir | HCV NS3/4A inhibitor | Probechem Biochemicals

Chemical Structure : Simeprevir

CAS No.: 923604-59-5

Simeprevir (TMC-435, TMC435, TMC435350, TMC-435350)

Catalog No.: PC-42480Not For Human Use, Lab Use Only.

Simeprevir (TMC435, TMC435350) is a potent, orally available inhibitor of HCV NS3/4A protease with Ki of 0.36 nM, replicon EC50 of 7.8 nM.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
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Biological Activity

Simeprevir (TMC435, TMC435350) is a potent, orally available inhibitor of HCV NS3/4A protease with Ki of 0.36 nM, replicon EC50 of 7.8 nM.
Simeprevir inhibits NS3/4A proteases of genotypes 1a and 1b with Ki of 0.5 and 0.4 nM, shows synergistic effect with α-Interferon and an NS5B inhibitor in the replicon model and additive with ribavirin.
Simeprevir exerts favorable pharmacokinetic profile and antiviral activity in vivo.

Physicochemical Properties

M.Wt	749.9391
Formula	C38H47N5O7S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide, N-(cyclopropylsulfonyl)-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-, (2R,3aR,1

References

1. Raboisson P, et al. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8.

2. Lin TI, et al. Antimicrob Agents Chemother. 2009 Apr;53(4):1377-85.

3. Lenz O, et al. Antimicrob Agents Chemother. 2010 May;54(5):1878-87.

Simeprevir (TMC-435, TMC435, TMC435350, TMC-435350)

Biological Activity

Physicochemical Properties

References

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