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Simpinicline

Chemical Structure : Simpinicline

CAS No.: 753015-44-0

Simpinicline (OC-02)

Catalog No.: PC-38681Not For Human Use, Lab Use Only.

Simpinicline (OC-02) is a highly selective nicotinic acetylcholine receptor (nAChR) agonist, exhibits potent antiviral activity against the SARS-CoV-2 variants in cell culture with IC50 of 40 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Simpinicline (OC-02) is a highly selective nicotinic acetylcholine receptor (nAChR) agonist, exhibits potent antiviral activity against the SARS-CoV-2 variants in cell culture with IC50 of 40 nM.

Physicochemical Properties

M.Wt 175.235
Formula C10H13N3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-{(1E)-2-[(3R)-pyrrolidin-3-yl]ethen-1-yl}pyrimidine

References

1. Alexandris, N. et al. Toxicology reports, 8, 73-83.

2. Sungnak, W.,et al. Nature medicine, 26(5), 681-687.

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