Simtuzumab
(Anti-human LOXL2 mAb, human IgG4-Kappa; GS-6624)
Catalog No.: PC-Ab1092Not For Human Use, Lab Use Only.
Simtuzumab (SIM, GS-6624) is a humanized IgG1 antibody against lysyl oxidase like-2 (LOXL2). Simtuzumab binds to LOXL2, was shown to have a role in suppressing bleomycin-induced pulmonary fibrosis in a murine model. pecifically target and block the LOXL2 which has been assigned to an important role in fibrosis. Besidesm, LOXL2 is one of several secreted copper-binding amine oxidases that oxidize primary amine substrates to aldehydes. It is widely expressed, particularly in placenta, uterus, and
Simtuzumab (SIM, GS-6624) is a humanized IgG1 antibody against lysyl oxidase like-2 (LOXL2). Simtuzumab binds to LOXL2, was shown to have a role in suppressing bleomycin-induced pulmonary fibrosis in a murine model. pecifically target and block the LOXL2 which has been assigned to an important role in fibrosis. Besidesm, LOXL2 is one of several secreted copper-binding amine oxidases that oxidize primary amine substrates to aldehydes. It is widely expressed, particularly in placenta, uterus, and prostate. LOXL2 is upregulated during cancer progression and promotes cell migration and tumor cell invasiveness.
Physicochemical Properties
M.Wt
Formula
Human IgG4-Kappa
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
PBS, pH 7.0
Contains no stabilizers or preservatives
