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Simvastatin

Chemical Structure : Simvastatin

CAS No.: 79902-63-9

Simvastatin (MK-733, MK733)

Catalog No.: PC-45300Not For Human Use, Lab Use Only.

Simvastatin (MK-733) is a potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with Kd of 0.1-0.2 nM.

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Biological Activity

Simvastatin (MK-733) is a potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with Kd of 0.1-0.2 nM.
Simvastatin (MK-733) inhibits cholesterol synthesis in mouse L-M cell (fibroblast), rat H4II E cell (liver), and human Hep G2 cell (liver) with IC50 of 19.3 nM, 13.3 nM and 15.6 nM, respectively.
Simvastatin (MK-733) also shows anti-inflammatory activity in inflammatory arthritis.

Physicochemical Properties

M.Wt 418.5662
Formula C25H38O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester

References

1. Kureishi Y, et al. Nat Med. 2000 Sep;6(9):1004-10.

2. Slater EE, et al. Drugs. 1988;36 Suppl 3:72-82.

3. Leung BP, et al. J Immunol. 2003 Feb 1;170(3):1524-30.

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