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Chemical Structure : Simvastatin
CAS No.: 79902-63-9
Catalog No.: PC-45300Not For Human Use, Lab Use Only.
Simvastatin (MK-733) is a potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with Kd of 0.1-0.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $78 | In stock | |
| 100 mg | $118 | In stock | |
| 250 mg | $198 | In stock | |
| 500 mg | $328 | In stock | |
| 1 g | Get quote |
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Simvastatin (MK-733) is a potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with Kd of 0.1-0.2 nM.
Simvastatin (MK-733) inhibits cholesterol synthesis in mouse L-M cell (fibroblast), rat H4II E cell (liver), and human Hep G2 cell (liver) with IC50 of 19.3 nM, 13.3 nM and 15.6 nM, respectively.
Simvastatin (MK-733) also shows anti-inflammatory activity in inflammatory arthritis.
| M.Wt | 418.5662 | |
| Formula | C25H38O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester |
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1. Kureishi Y, et al. Nat Med. 2000 Sep;6(9):1004-10.
2. Slater EE, et al. Drugs. 1988;36 Suppl 3:72-82.
3. Leung BP, et al. J Immunol. 2003 Feb 1;170(3):1524-30.
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