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Sirt2 PROTAC 1

Chemical Structure : Sirt2 PROTAC 1

CAS No.: 2098487-75-1

Sirt2 PROTAC 1

Catalog No.: PC-60096Not For Human Use, Lab Use Only.

Sirt2 PROTAC 1 is a SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Sirt2 PROTAC 1 is a SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM).

Physicochemical Properties

M.Wt 852.942
Formula C40H40N10O8S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(3-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)thiazol-2-yl)acetamide

References

1. Schiedel M, et al. J Med Chem. 2017 Apr 17. doi: 10.1021/acs.jmedchem.6b01872.

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