Catalog No.: PC-45971Not For Human Use, Lab Use Only.
Sitaxsentan (IPI-1040, Sitaxentan) is a potent, long acting, orally active, selective ETA receptor antagonist that binds competitively to human ETA receptor with Ki of 0.43 nM, IC50 of 1.4 nM.
Sitaxsentan (IPI-1040, Sitaxentan) is a potent, long acting, orally active, selective ETA receptor antagonist that binds competitively to human ETA receptor with Ki of 0.43 nM, IC50 of 1.4 nM.
Sitaxsentan dispalys >5,000-fold selectivity over ETB receptors.
Sitaxsentan inhibits ET1-induced stimulation of phosphoinositide turnover with Ki of 0.686 nM, and pA2 of 8.0.
Sitaxsentan shows excellent PK profile and oral bioavailability.
