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Chemical Structure : Sivelestat sodium
CAS No.: 150374-95-1
Catalog No.: PC-45265Not For Human Use, Lab Use Only.
Sivelestat (EI-546;LY-544349;ONO-5046) sodium is a potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
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Sivelestat (EI-546;LY-544349;ONO-5046) sodium is a potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM.
Sivelestat also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse, does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G (>10 uM).
Sivelestat attenuates LPS-induced acute lung inflammation in the hamster.
| M.Wt | 456.4447 | |
| Formula | C20H21N2NaO7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester, sodium salt (1:1) |
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1. Kawabata K, et al. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20.
2. Yasui S, et al. Eur Respir J. 1995 Aug;8(8):1293-9.
3. Sakamaki F, et al. Am J Respir Crit Care Med. 1996 Jan;153(1):391-7.
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