Skp2-2

Chemical Structure : Skp2-2

Catalog No.: PC-21056Not For Human Use, Lab Use Only.

Skp2-2 is a small molecule inhibitor of Skp2-Cks1 interaction with IC50 of 27.8 uM, significantly and dose-dependently reduces the protein expression of Skp2 in cancer cells.

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Biological Activity

Skp2-2 is a small molecule inhibitor of Skp2-Cks1 interaction with IC50 of 27.8 uM, significantly and dose-dependently reduces the protein expression of Skp2 in cancer cells.
Skp2-2 increases the protein levels of p21 and p27, inhibit Skp2 expression up to 90%, in SGC-7901, a gastric cancer cell with high Skp2 expression.
Skp2-2 also influence the mRNA levels of Skp2, p21, and p27, showed significant S-phase arrest, with the proportion of S-phase.

Physicochemical Properties

M.Wt	298.36
Formula	C16H14N2O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-phenyl-N-(quinolin-8-yl)methanesulfonamide

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Skp2-2

Biological Activity

Physicochemical Properties

References

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