Chemical Structure : SmcR inhibitor PTSP
CAS No.:
2762184-06-3
SmcR inhibitor PTSP
Catalog No.: PC-27136Not For Human Use, Lab Use Only.
PTSP is a specific and potent inhibitor of Vibrio LuxR/HapR proteins and LuxR homolog SmcR in Vibrio vulnificus, inhibits quorum sensing in multiple strains of V. vulnificus, V. parahaemolyticus, and V. campbellii.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PTSP is a specific and potent inhibitor of Vibrio LuxR/HapR proteins and LuxR homolog SmcR in Vibrio vulnificus, inhibits quorum sensing in multiple strains of V. vulnificus, V. parahaemolyticus, and V. campbellii.
PTSP significantly reduces protease activity in V. campbellii, V. coralliilyticus, and V. vulnificus, but not in V. cholerae, with IC50 of 6.8 nM, 78.1 nM and 18.3 nM for V. vulnificus strains ATCC 27562, CMPC6 and YJ016.
PTSP has a lower dissociation constant (Kd) for SmcR (0.23 μM) compared to LuxR (0.51 μM).
PTSP binds to SmcR drives allosteric unfolding of the N-terminal DNA-binding domain, induces it's specifically degradation by the ClpAP protease.
Physicochemical Properties
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M.Wt
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290.36
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Formula
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C13H10N2O2S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-phenyl-1-(thiophen-2-ylsulfonyl)-1H-pyrazole
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References
1. Rasal TA, et al. mBio. 2026 Mar 11;17(3):e0344525.
2. Newman JD, et al. Mol Microbiol. 2021 Oct;116(4):1173-1188.
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