Catalog No.: PC-21766Not For Human Use, Lab Use Only.
Smurf1 inhibitor A01 is a specific small molecule inhibitor of ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) with Kd of 3.66 nM for interrupting Smurf1-Smad1 interaction, impairs Smurf1-mediated Smad1/5 degradation and stabilizes Smad1/5 protein level.
Smurf1 inhibitor A01 is a specific small molecule inhibitor of ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) with Kd of 3.66 nM for interrupting Smurf1-Smad1 interaction, impairs Smurf1-mediated Smad1/5 degradation and stabilizes Smad1/5 protein level.
Smurf1 inhibitor A01 does not affect the protein level of Smad2/3, Smad4, ING2 and the small guanosine triphosphatase RhoA.
Smurf1 inhibitor A01 does not interrupt Smurf2-Smad2 or Smurf2-Smad3 interactions.
Smurf1 inhibitor A01 (2 uM) enhances BMP signaling responsiveness in C2C12 and mouse pre-osteoblasts MC3T3-E1 cells, induces gene expression of ALP, osteocalcin and type I collagen (α1).
Smurf1 inhibitor A01 (10 uM) potentiates BMP-2 induced osteoblastic activity in both C2C12 and MC3T3-E1 cells, potentiates BMP-2 induced ALP enrichment.
