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Chemical Structure : Sofnobrutinib
Catalog No.: PC-35698Not For Human Use, Lab Use Only.
Sofnobrutinib (AS-0871, BTK inhibitor 4b) is a potent, highly selective, non-covalent inhibitor of BTK with IC50 of 4.2 and 0.9 nM against activated and unactivated BTK, respectively.
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Sofnobrutinib (AS-0871, BTK inhibitor 4b) is a potent, highly selective, non-covalent inhibitor of BTK with IC50 of 4.2 and 0.9 nM against activated and unactivated BTK, respectively.
BTK inhibitor 4b demonstrates significant efficacy in models in vivo and good ADME and safety profiles.
| M.Wt | 498.522 | |
| Formula | C26H23FN8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kawahata W, et al. J Med Chem. 2018 Oct 11;61(19):8917-8933.
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