Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Sorafenib
CAS No.: 284461-73-0
Catalog No.: PC-42445Not For Human Use, Lab Use Only.
Sorafenib (Bay 43-9006) is a potent, orally available Raf inhibitor with IC50 of 6, 22, and 38 nM for Raf-1, wt Braf, and BRaf V599E, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg (Free Sample) | $28 | In stock | |
| 100 mg | $78 | In stock | |
| 250 mg | $128 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Sorafenib (Bay 43-9006) is a potent, orally available Raf inhibitor with IC50 of 6, 22, and 38 nM for Raf-1, wt Braf, and BRaf V599E, respectively.
Sorafenib (Bay 43-9006) also demonstrates potent inhibition of certain proangiogenic RTKs, including VEGFR-2, PDGFR-β, VEGFR-3, Flt-3, c-Kit (IC50<100 nM).
Sorafenib (Bay 43-9006) exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.
| M.Wt | 464.825 | |
| Formula | C21H16ClF3N4O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 45 mg/mL |
|
| Chemical Name/SMILES |
2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl- |
|
1. Wilhelm SM, et al. Cancer Res. 2004 Oct 1;64(19):7099-109.
2. Carlomagno F, et al. J Natl Cancer Inst. 2006 Mar 1;98(5):326-34.
4. Lyons JF, et al. Endocr Relat Cancer. 2001 Sep;8(3):219-25.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
