You are here:Home-Chemical Inhibitors & Agonists-Ras-Raf-MAPK-ERK Pathway-Raf-Sorafenib
Sorafenib

Chemical Structure : Sorafenib

CAS No.: 284461-73-0

Sorafenib (Bay 43-9006, Bay43-9006)

Catalog No.: PC-42445Not For Human Use, Lab Use Only.

Sorafenib (Bay 43-9006) is a potent, orally available Raf inhibitor with IC50 of 6, 22, and 38 nM for Raf-1, wt Braf, and BRaf V599E, respectively.

Packing Price Stock Quantity
10 mg (Free Sample) $28 In stock
100 mg $78 In stock
250 mg $128 In stock
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Sorafenib (Bay 43-9006) is a potent, orally available Raf inhibitor with IC50 of 6, 22, and 38 nM for Raf-1, wt Braf, and BRaf V599E, respectively.
Sorafenib (Bay 43-9006) also demonstrates potent inhibition of certain proangiogenic RTKs, including VEGFR-2, PDGFR-β, VEGFR-3, Flt-3, c-Kit (IC50<100 nM).
Sorafenib (Bay 43-9006) exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.

Physicochemical Properties

M.Wt 464.825
Formula C21H16ClF3N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 45 mg/mL

Chemical Name/SMILES

2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-

References

1. Wilhelm SM, et al. Cancer Res. 2004 Oct 1;64(19):7099-109.

2. Carlomagno F, et al. J Natl Cancer Inst. 2006 Mar 1;98(5):326-34.

4. Lyons JF, et al. Endocr Relat Cancer. 2001 Sep;8(3):219-25.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: