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Chemical Structure : Sorafenib tosylate
CAS No.: 475207-59-1
Catalog No.: PC-42446Not For Human Use, Lab Use Only.
Sorafenib (Bay 43-9006) tosylate is a potent, orally available Raf inhibitor with IC50 of 6, 22, and 38 nM for Raf-1, wt Braf, and BRaf V599E, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg (Free Sample) | $28 | In stock | |
| 50 mg | $88 | In stock | |
| 100 mg | $128 | In stock | |
| 250 mg | $198 | In stock | |
| 1 g | Get quote |
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Sorafenib (Bay 43-9006) tosylate is a potent, orally available Raf inhibitor with IC50 of 6, 22, and 38 nM for Raf-1, wt Braf, and BRaf V599E, respectively.
Sorafenib also demonstrates potent inhibition of certain proangiogenic RTKs, including VEGFR-2, PDGFR-β, VEGFR-3, Flt-3, c-Kit (IC50<100 nM).
Sorafenib exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.
| M.Wt | 637.0266 | |
| Formula | C28H24ClF3N4O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-, 4-methylbenzenesulfonate (1:1) |
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1. Wilhelm SM, et al. Cancer Res. 2004 Oct 1;64(19):7099-109.
2. Carlomagno F, et al. J Natl Cancer Inst. 2006 Mar 1;98(5):326-34.
4. Lyons JF, et al. Endocr Relat Cancer. 2001 Sep;8(3):219-25.
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