Sovesudil (PHP-201, AMA0076)

Chemical Structure : Sovesudil

CAS No.: 1333400-14-8

Catalog No.: PC-27871Not For Human Use, Lab Use Only.

Sovesudil (PHP-201, AMA0076) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50 of 3.7 nM and 2.3 nM for ROCK1 and ROCK2, respectively.

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Biological Activity

Sovesudil (PHP-201, AMA0076) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50 of 3.7 nM and 2.3 nM for ROCK1 and ROCK2, respectively.

Physicochemical Properties

M.Wt	407.45
Formula	C23H22FN3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Propyl 2'-(aminomethyl)-5'-((3-fluoropyridin-4-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylate

References

1. Ha A, et al. Acta Ophthalmol. 2022 Mar;100(2):e470-e477.

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