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Spiropiperidine 1

Chemical Structure : Spiropiperidine 1

CAS No.: 2733824-83-2

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Spiropiperidine 1 (SPP1)

Catalog No.: PC-35835Not For Human Use, Lab Use Only.

Spiropiperidine 1 (SPP1) is a potent, functionally selective and brain penetrant M1 orthosteric agonist with Ki of 21.3 nM for hM1 receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Spiropiperidine 1 (SPP1) is a potent, functionally selective and brain penetrant M1 orthosteric agonist with Ki of 21.3 nM for hM1 receptors.
    Spiropiperidine 1 stimulates Gq mediated GTPγ[35S] signaling with IC50 of 12.3 nM, stimulates Gq mediated signaling in membranes prepared from rat cortex with EC50 of 21 nM。
    Spiropiperidine 1 displays high functional selectivity for M1 receptors over native M2 and M3 receptor anti-targets and over a panel of other targets.

    Physicochemical Properties

    M.Wt 426.561
    Formula C24H34N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    cyclopropyl 4-(3-methyl-4-oxo-1-(m-tolyl)-1,3,8-triazaspiro[4.5]decan-8-yl)piperidine-1-carboxylate

    References

    1. Broad LM, et al. Br J Pharmacol. 2018 Oct 1. doi: 10.1111/bph.14510.

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