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Chemical Structure : Spiropiperidine 1
Catalog No.: PC-35835Not For Human Use, Lab Use Only.
Spiropiperidine 1 (SPP1) is a potent, functionally selective and brain penetrant M1 orthosteric agonist with Ki of 21.3 nM for hM1 receptors.
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Spiropiperidine 1 (SPP1) is a potent, functionally selective and brain penetrant M1 orthosteric agonist with Ki of 21.3 nM for hM1 receptors.
Spiropiperidine 1 stimulates Gq mediated GTPγ[35S] signaling with IC50 of 12.3 nM, stimulates Gq mediated signaling in membranes prepared from rat cortex with EC50 of 21 nM。
Spiropiperidine 1 displays high functional selectivity for M1 receptors over native M2 and M3 receptor anti-targets and over a panel of other targets.
| M.Wt | 426.561 | |
| Formula | C24H34N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Broad LM, et al. Br J Pharmacol. 2018 Oct 1. doi: 10.1111/bph.14510.
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