Chemical Structure : Splitomicin
CAS No.: 5690-03-9
Catalog No.: PC-70234Not For Human Use, Lab Use Only.
Splitomicin (1-Naphthalenepropanoic Acid) is a selecitve small molecule inhibitor of Sir2p histone deacetylase, displaying higher activity in vivo (minimal inhibitory concentration= 0.49 uM) than in vitro (IC50=60 uM).
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Splitomicin (1-Naphthalenepropanoic Acid) is a selecitve small molecule inhibitor of Sir2p histone deacetylase, displaying higher activity in vivo (minimal inhibitory concentration= 0.49 uM) than in vitro (IC50=60 uM).
Splitomicin less effectively inhibits yeast Hst1.
M.Wt | 198.2 | |
Formula | C13H10O2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
1,2-dihydro-3H-naphtho[2,1-b]pyran-3-one |
1. Bedalov A, et al. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15113-8.
2. Hirao M, et al. J Biol Chem. 2003 Dec 26;278(52):52773-82.
3. Liu FC, et al. Eur J Pharmacol. 2012 Aug 5;688(1-3):68-75.
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