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Stafori-1

Chemical Structure : Stafori-1

CAS No.:

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Stafori-1 (STAT four inhibitor-1)

Catalog No.: PC-24234Not For Human Use, Lab Use Only.

Stafori-1 is the first specific small-molecule inhibitor of STAT4, inhibits the protein-protein interaction domain of STAT4, the SH2 domain, with Ki of 1.7 uM, 10-70-fold selectivity over other STAT proteins.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Stafori-1 is the first specific small-molecule inhibitor of STAT4, inhibits the protein-protein interaction domain of STAT4, the SH2 domain, with Ki of 1.7 uM, 10-70-fold selectivity over other STAT proteins.
Stafori-1 selectively stabilized STAT4 against thermaldenaturation in cell lysate.

Physicochemical Properties

M.Wt 322.24
Formula C12H10F3O3PS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(difluoro(2-fluoro-4-(5-methylthiophen-3-yl)phenyl)methyl)phosphonic acid

References

1. Angew Chem Int Ed Engl. 2025 Mar 11:e202504420.

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