Catalog No.: PC-21893Not For Human Use, Lab Use Only.
Stattic is a potent, selective nonpeptidic STAT3 inhibitor, inhibits the function of the STAT3 SH2 domain (IC50=5.1 uM) regardless of the STAT3 activation state in vitro.
Stattic is a potent, selective nonpeptidic STAT3 inhibitor, inhibits the function of the STAT3 SH2 domain (IC50=5.1 uM) regardless of the STAT3 activation state in vitro.
Stattic selectively inhibits activation, dimerization, and nuclear translocation of STAT3 and increases the apoptotic rate of STAT3-dependent breast cancer cell lines.
Stattic inhibits STAT3 phosphorylation (at Y705 and S727).
Stattic is a useful tool for the inhibition of STAT3 in cell lines or animal tumor models displaying constitutive STAT3 activation.
Physicochemical Properties
M.Wt
211.19
Formula
C8H5NO4S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
6-Nitrobenzo[b]thiophene 1,1-dioxide
References
1. John S McMurray, et al. Chem Biol. 2006 Nov;13(11):1123-4.
