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Chemical Structure : Stattic
CAS No.: 19983-44-9
Catalog No.: PC-21893Not For Human Use, Lab Use Only.
Stattic is a potent, selective nonpeptidic STAT3 inhibitor, inhibits the function of the STAT3 SH2 domain (IC50=5.1 uM) regardless of the STAT3 activation state in vitro.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $68 | In stock | |
| 50 mg | $108 | In stock | |
| 100 mg | $158 | In stock | |
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| 1 g | Get quote |
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Stattic is a potent, selective nonpeptidic STAT3 inhibitor, inhibits the function of the STAT3 SH2 domain (IC50=5.1 uM) regardless of the STAT3 activation state in vitro.
Stattic selectively inhibits activation, dimerization, and nuclear translocation of STAT3 and increases the apoptotic rate of STAT3-dependent breast cancer cell lines.
Stattic inhibits STAT3 phosphorylation (at Y705 and S727).
Stattic is a useful tool for the inhibition of STAT3 in cell lines or animal tumor models displaying constitutive STAT3 activation.
| M.Wt | 211.19 | |
| Formula | C8H5NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-Nitrobenzo[b]thiophene 1,1-dioxide |
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1. John S McMurray, et al. Chem Biol. 2006 Nov;13(11):1123-4.
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