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Chemical Structure : Streptonigrin
CAS No.: 3930-19-6
Catalog No.: PC-61919Not For Human Use, Lab Use Only.
Streptonigrin (Bruneomycin, NSC 45383) is a potent, selective, and irreversible PAD4 inactivator with IC50 of 1.87 uM, also binds directly to RAD54 with Kd of 9.1 uM, inhibits ATPase and DNA branch migration activity of RAD54.
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Streptonigrin (Bruneomycin, NSC 45383) is a potent, selective, and irreversible PAD4 inactivator with IC50 of 1.87 uM, also binds directly to RAD54 with Kd of 9.1 uM, inhibits ATPase and DNA branch migration activity of RAD54.
Streptonigrin inhibits branch migration of model Holliday junctions with IC50 of 16.5 uM.
Streptonigrin inhibits ATP hydrolysis with IC50 of 14.4 uM, also binds and inhibits the SUMO-specific protease SENP1.
| M.Wt | 506.471 | |
| Formula | C25H22N4O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(4Z)-5-amino-6-(7-amino-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(4,5-dimethoxy-6-oxocyclohexa-2,4-dien-1-ylidene)-3-methyl-1H-pyridine-2-carboxylic acid |
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1. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.
2. Deakyne JS, et al. J Biol Chem. 2013 Nov 1;288(44):31567-80.
3. Dreyton CJ, et al. Bioorg Med Chem. 2014 Feb 15;22(4):1362-9.
4. Knuckley B, et al. Chem Commun (Camb). 2010 Oct 14;46(38):7175-7.
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