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Sudemycin K

Chemical Structure : Sudemycin K

CAS No.: 2071636-70-7

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Sudemycin K

Catalog No.: PC-62422Not For Human Use, Lab Use Only.

Sudemycin K is a synthetic antitumor splicing inhibitor with IC50 of 15 nM (MCL1 alternative splicing regulation), shows cytotoxicity in HeLa cells with IC50 of 2.3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Sudemycin K is a synthetic antitumor splicing inhibitor with IC50 of 15 nM (MCL1 alternative splicing regulation), shows cytotoxicity in HeLa cells with IC50 of 2.3 nM.
    Sudemycin K has an IC50 of 250 nM in vitro spliceosome (A3’ complex) formation assays.

    Physicochemical Properties

    M.Wt 486.697
    Formula C29H46N2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S,Z)-N-((1R,4R)-4-((2E,4E)-5-((3R,5S)-7,7-dimethyl-1,6-dioxaspiro[2.5]octan-5-yl)-3-methylpenta-2,4-dien-1-yl)cyclohexyl)-4-isobutyramidopent-2-enamide

    References

    1. Makowski K, et al. ACS Chem Biol. 2017 Jan 20;12(1):163-173.

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