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Sulindac

Chemical Structure : Sulindac

CAS No.: 38194-50-2

Sulindac (MK-231, MK231)

Catalog No.: PC-27217Not For Human Use, Lab Use Only.

Sulindac (MK-231) is a nonsteroidal anti-inflammatory drug (NSAID) and inhibitor of cyclooxygenase-1 (COX-1) and COX-2, inhibits tumor growth via COX-2 suppression, exhibits anti-proliferative and anti-invasive effects and enhances the sensitivity to paclitaxel in ovarian cancer.

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500 mg $58 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Sulindac (MK-231) is a nonsteroidal anti-inflammatory drug (NSAID) and inhibitor of cyclooxygenase-1 (COX-1) and COX-2, inhibits tumor growth via COX-2 suppression, exhibits anti-proliferative and anti-invasive effects and enhances the sensitivity to paclitaxel in ovarian cancer.

Physicochemical Properties

M.Wt 356.41
Formula C20H17FO3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(Z)-2-(5-Fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetic acid

References

1. Fasching U, et al. Wien Klin Wochenschr Suppl. 1976;59:1-10.

2. Cohen A. Clin Pharmacol Ther. 1976 Aug;20(2):238-40.

3. Chen S, et al. Front Pharmacol. 2025 Apr 30;16:1520771.

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