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Chemical Structure : Sunobinop
Catalog No.: PC-21949Not For Human Use, Lab Use Only.
Sunobinop is a potent and partial agonist of the nociceptin/orphanin FQ peptide receptor (NOP receptor) with Ki of 3.3 nM, EC50 of 4.03 nM.
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Sunobinop is a potent and partial agonist of the nociceptin/orphanin FQ peptide receptor (NOP receptor) with Ki of 3.3 nM, EC50 of 4.03 nM.
Sunobinop competitively inhibited [3H]-NOP-1A binding in rat-brain sections with IC50 of 7.7 nM.
Sunobinop does not activate human μ and κ receptors and is a low-affinity, weak partial agonist at human δ receptors.
Sunobinop promotes non-REM sleep in rodents and patients with insomnia.
| M.Wt | 435.57 | |
| Formula | C26H33N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Whiteside GT, et al. J Clin Invest. 2024 Jan 2;134(1):e171172.
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