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Sunobinop

Chemical Structure : Sunobinop

CAS No.: 1126793-40-5

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Sunobinop (S 117957, IMB 115)

Catalog No.: PC-21949Not For Human Use, Lab Use Only.

Sunobinop is a potent and partial agonist of the nociceptin/orphanin FQ peptide receptor (NOP receptor) with Ki of 3.3 nM, EC50 of 4.03 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Sunobinop is a potent and partial agonist of the nociceptin/orphanin FQ peptide receptor (NOP receptor) with Ki of 3.3 nM, EC50 of 4.03 nM.
    Sunobinop competitively inhibited [3H]-NOP-1A binding in rat-brain sections with IC50 of 7.7 nM.
    Sunobinop does not activate human μ and κ receptors and is a low-affinity, weak partial agonist at human δ receptors.
    Sunobinop promotes non-REM sleep in rodents and patients with insomnia.

    Physicochemical Properties

    M.Wt 435.57
    Formula C26H33N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-Quinoxalinecarboxylic acid, 4-[(3-endo)-9-(3-exo)-bicyclo[3.3.1]non-3-yl-9-azabicyclo[3.3.1]non-3-yl]-3,4-dihydro-3-oxo-

    References

    1. Whiteside GT, et al. J Clin Invest. 2024 Jan 2;134(1):e171172.

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