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Suraxavir marboxil

Chemical Structure : Suraxavir marboxil

CAS No.: 2364589-86-4

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Suraxavir marboxil (GP681, GP-681)

Catalog No.: PC-24187Not For Human Use, Lab Use Only.

Suraxavir marboxil (GP681) is an orally bioavailable antiviral drug inhibiting the polymerase acidic protein (PA) of RNA polymerase of influenza virus, demonstrates nanomolar antiviral activity against both influenza A and B viruses with the average IC50 on the transcriptional activity of 0.6 nM, EC90 of 6.9 ng/mL.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Suraxavir marboxil (GP681) is an orally bioavailable antiviral drug inhibiting the polymerase acidic protein (PA) of RNA polymerase of influenza virus, demonstrates nanomolar antiviral activity against both influenza A and B viruses with the average IC50 on the transcriptional activity of 0.6 nM, EC90 of 6.9 ng/mL.
suraxavir showed viral suppression comparable to oseltamivir and baloxavir.

Physicochemical Properties

M.Wt 597.59
Formula C29H25F2N3O7S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(((R)-12'-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-6',8'-dioxo-6',8',12',12a'-tetrahydro-1'H,4'H-spiro[cyclopropane-1,3'-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin]-7'-yl)oxy)methyl methyl carbonate

References

1. Wang Y, et al. Nat Med. 2025 Feb;31(2):639-646.

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