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Susineridine

Chemical Structure : Susineridine

CAS No.: 2667632-87-1

Susineridine (YZJ-4729)

Catalog No.: PC-26358Not For Human Use, Lab Use Only.

Susineridine (YZJ-4729) is a G protein-biased μ-opioid receptor (MOR) agonist with EC50 of 17 nM, also demonstrates certain antagonistic effects on KOR and DOR, with IC50 of 1.100 μM and 6.962 μM, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Susineridine (YZJ-4729) is a G protein-biased μ-opioid receptor (MOR) agonist with EC50 of 17 nM, also demonstrates certain antagonistic effects on KOR and DOR, with IC50 of 1.100 μM and 6.962 μM, respectively.

Physicochemical Properties

M.Wt 408.59
Formula C25H36N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4H-Pyrrolo[1,2-b]pyrazol-4-amine, 5,6-dihydro-6-(1-methylethyl)-N-[2-[(9R)-9-(2-pyridinyl)-6-oxaspiro[4.5]dec-9-yl]ethyl]-, (4S,6S)-

References

1. Ni Y, et al. Front Pharmacol. 2024 Jan 9;14:1295319.

2. Patent WO2023284788 A1.

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