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Sutimlimab

Chemical Structure : Sutimlimab

CAS No.:

Sutimlimab (Anti-human C1s mAb, human IgG4-Kappa; BIVV009)

Catalog No.: PC-Ab1041Not For Human Use, Lab Use Only.

Sutimlimab (BIVV009, TNT-009) is a humanized mAb that specifically inhibits the complement (CP)-specific serine protease C1s to evaluate the impact of upstream CP antagonism on activation and proliferation of normal and autoimmune human B cells. Sutimlimab potentially reduce RBC lysis, significantly inhibited complement-mediated activation and proliferation of primary human B cells. antagonism suppressed human Ig-induced activation of B cells derived from patients with rheumatoid arthritis..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Sutimlimab (BIVV009, TNT-009) is a humanized mAb that specifically inhibits the complement (CP)-specific serine protease C1s to evaluate the impact of upstream CP antagonism on activation and proliferation of normal and autoimmune human B cells. Sutimlimab potentially reduce RBC lysis, significantly inhibited complement-mediated activation and proliferation of primary human B cells. antagonism suppressed human Ig-induced activation of B cells derived from patients with rheumatoid arthritis.

Physicochemical Properties

M.Wt
Formula Human IgG4-Kappa
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives

Chemical Name/SMILES

References

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