T‐495 | M1 mAChR PAM | Probechem Biochemicals

Chemical Structure : T‐495

Catalog No.: PC-23644Not For Human Use, Lab Use Only.

T-495 is a potent and highly selective positive allosteric modulator of M1 muscarinic acetylcholine receptor with EC50 of 649 nM.

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Biological Activity

T-495 is a potent and highly selective positive allosteric modulator of M1 muscarinic acetylcholine receptor with EC50 of 649 nM.

M.Wt	407.29
Formula	C20H20Cl2N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-chloro-6-((6-chloropyridin-3-yl)methyl)-3-((1S,2S)-2-hydroxycyclopentyl)-7-methyl-2,3-dihydro-4H-benzo[e][1,3]oxazin-4-one

1. Takao Mandai, et al. Pharmacol Res Perspect. 2020 Feb;8(1):e00560.