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T-00127-HEV1

Chemical Structure : T-00127-HEV1

CAS No.: 900874-91-1

T-00127-HEV1 (PI4KB inhibitor)

Catalog No.: PC-63343Not For Human Use, Lab Use Only.

T-00127-HEV1 is a broad-spectrum antienterovirus compound that selectively inhibits PI4KB activity with IC50 of 60 nM, inhibits poliovirus pseudovirus and EV71 in RD cells with IC50 of 0.77 and 0.73 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

T-00127-HEV1 is a broad-spectrum antienterovirus compound that selectively inhibits PI4KB activity with IC50 of 60 nM, inhibits poliovirus pseudovirus and EV71 in RD cells with IC50 of 0.77 and 0.73 uM.
T-00127-HEV1 shows a moderate inhibitory effect on PIK3CD activity, and high selectivity over other PI kinases.
T-00127-HEV1 demonstrates antipoliovirus activity ,does not inhibit hepatitis C virus (HCV) replication.

Physicochemical Properties

M.Wt 411.506
Formula C22H29N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(3,4-dimethoxyphenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine

References

1. Arita M, et al. J Virol. 2011 Mar;85(5):2364-72.

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