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Chemical Structure : T-3256336
Catalog No.: PC-61034Not For Human Use, Lab Use Only.
T-3256336 is a potent, selective, orally available IAP antagonist with IC50 of 1.3, 2.2 and 200 nM for cIAP-1, cIAP-2 and XIAP, respectively.
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T-3256336 is a potent, selective, orally available IAP antagonist with IC50 of 1.3, 2.2 and 200 nM for cIAP-1, cIAP-2 and XIAP, respectively.
T-3256336 dose dependently antagonizes XIAP and promotes the activities of caspase-3 with EC50 of 1.3 uM in cell-free assays.
T-3256336 induces the rapid proteasomal degradation of cIAP-1 and activates TNF-α-dependent extrinsic apoptosis signaling in cultured cells.
T-3256336 induces cIAP-1 degradation, TNF-α production and caspase activation in cancer xenograft models.
| M.Wt | 605.728 | |
| Formula | C31H45F2N5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sumi H, et al. Mol Cancer Ther. 2013 Feb;12(2):230-40.
2. Hashimoto K, et al. J Med Chem. 2013 Feb 14;56(3):1228-46.
3. Sumi H, et al. Biochem Biophys Res Commun. 2016 Oct 14;479(2):179-185.
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