Chemical Structure : T-3764518
CAS No.:
1809151-56-1
T-3764518
(T 3764518;T3764518)
Catalog No.: PC-60369Not For Human Use, Lab Use Only.
T-3764518 (T 3764518, T3764518) is a novel potent, orally active SCD1 inhibitor with binding IC50 of 4.7 nM for hSCD1.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
T-3764518 (T 3764518, T3764518) is a novel potent, orally active SCD1 inhibitor with binding IC50 of 4.7 nM for hSCD1; induces phosphorylation and activation of AMPK in HCT-116 cells, which led to blockade of downstream fatty acid synthesis and acceleration of autophagy; shows significant pharmacodynamic marker reduction (at 0.3mg/kg, bid) in HCT116 mouse xenograft model and tumor growth suppression (at 1mg/kg, bid) in 786-O mouse xenograft model; exhibits an excellent PK profile.
Physicochemical Properties
|
M.Wt
|
473.379
|
|
Formula
|
C20H17F6N5O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20 °C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80 °C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(5-(6-(4-(Trifluoromethyl)-4-(4-(trifluoromethyl)phenyl)
piperidin-1-yl)pyridazin-3-yl)-1,3,4-oxadiazol-2-yl)methanol
|
References
1. Imamura K, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3768-3779.
2. Nishizawa S, et al. Eur J Pharmacol. 2017 Jul 15;807:21-31.
3. Ono A, et al. PLoS One. 2017 Jul 13;12(7):e0181243.
Contact Us
sales@probechem.com
