T0080 | FPR1 antagonist | Probechem Biochemicals

Chemical Structure : T0080

T0080 (T-0080)

Catalog No.: PC-25756Not For Human Use, Lab Use Only.

T0080 is a potent, selective, CNS-penetrating formyl peptide receptor 1 (FPR1) antagonist, reduces brain inflammation and neurodegeneration in animal model of multiple sclerosis (MS).

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Biological Activity

T0080 is a potent, selective, CNS-penetrating formyl peptide receptor 1 (FPR1) antagonist, reduces brain inflammation and neurodegeneration in animal model of multiple sclerosis (MS).

Physicochemical Properties

M.Wt	457.45
Formula	C24H22F3N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyrrolo[3,4-c]pyrazol-6(2H)-one, 4,5-dihydro-3-(2-hydroxy-5-methylphenyl)-5-(tetrahydro-2H-pyran-4-yl)-4-[4-(trifluoromethyl)phenyl]-

References

1. Li Y, et al. Targeting formyl peptide receptor 1 reduces brain inflammation and neurodegeneration. Science. 2025 Nov 13;390(6774):eadq1177.

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T0080 (T-0080)

Biological Activity

Physicochemical Properties

References

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