Chemical Structure : T0467
CAS No.:
859518-94-8
T0467
(T 0467)
Catalog No.: PC-20550Not For Human Use, Lab Use Only.
T0467 is a small molecule activator of PINK1-Parkin signaling, activates Parkin mitochondrial translocation in dopaminergic neurons and myoblasts (20 uM, 3h), does not induce mitochondrial accumulation of PINK1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
T0467 is a small molecule activator of PINK1-Parkin signaling, activates Parkin mitochondrial translocation in dopaminergic neurons and myoblasts (20 uM, 3h), does not induce mitochondrial accumulation of PINK1.
T0467 stimulates the mitochondrial translocation of Parkin in a PINK1-dependent manner.
T0467 reduces unfolded mitochondrial protein levels, presumably through enhanced PINK1-Parkin signaling.
T0467 mitigates the locomotion defect, reduced ATP production, and disturbed mitochondrial Ca2+ response in the muscles along with the mitochondrial aggregation in dopaminergic neurons through reduced PINK1 activity in Drosophila.
Physicochemical Properties
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M.Wt
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441.50
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Formula
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C24H26F3N5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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FC1=CC(CCNC2=NC(C3=C(F)C=CC(CN4CCNC[C@@H]4C)=C3)=CC=N2)=CC(F)=C1
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References
1. Shiba-Fukushima K, et al. iScience. 2020 May 22;23(5):101048.
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