T0901317 (TO901317) is a potent, high affinity LXR agonist (EC50=50 nM, Kd are 7 and 22 nM for LXR-α and LXR-β respectively).
T0901317 (TO901317) upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism.
T0901317 (TO901317) decreases amyloid-β production in primary neurons in vitro.
T0901317 (TO901317) displays an EC50 of ~ 5 μM for activation of FXRs.
T0901317 (TO901317) also is an inverse agonist of human constitutive androstane receptor (hCAR), blocks the interaction of hCAR with steroid receptor co-activator 1 (SRC1).
