Catalog No.: PC-72920Not For Human Use, Lab Use Only.
T2AA (T2 amino alcohol) is a small molecule proliferating cell nuclear antigen (PCNA) inhibitor, inhibits interaction of PCNA/PIP-box peptide with IC50 of 1 uM.
T2AA (T2 amino alcohol) is a small molecule proliferating cell nuclear antigen (PCNA) inhibitor, inhibits interaction of PCNA/PIP-box peptide with IC50 of 1 uM.
T2AA also inhibits interaction of PCNA and full-length p21 protein.
T2AA abolished interaction of PCNA and DNA polymerase δ in cellular chromatin, arrested cancer cells in S-phase, inhibited growth of cancer cells with induction of early apoptosis.
T2AA significantly inhibited translesion DNA synthesis on a cisplatin-cross-linked template in cells, induced significant increase in phospho(Ser139) histone H2AX induction and cell growth inhibition combined with cisplatin.;
