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T326

Chemical Structure : T326

CAS No.: 1451042-19-5

T326 (T 326;HDAC3 inhibitor T326)

Catalog No.: PC-60828Not For Human Use, Lab Use Only.

T326 is a potent and selective HDAC3 inhibitor with IC50 of 0.26 uM, with no activity against HDAC1/4/6/8.

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    Biological Activity

    T326 is a potent and selective HDAC3 inhibitor with IC50 of 0.26 uM, with no activity against HDAC1/4/6/8.
    T326 induces dose-dependent selective increase of NF-κB acetylation in human colon cancer HCT116 cells, induces growth inhibition of cancer cells, and activates HIV gene expression in latent HIV-infected cells.
    T326 shows promising activity for anticancer and antiviral benefits.

    Physicochemical Properties

    M.Wt 434.474
    Formula C21H18N6O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(2-aminophenyl)-5-(1-(3-nitrophenethyl)-1H-1,2,3-triazol-4-yl)thiophene-2-carboxamide

    References

    1. Suzuki T, et al. PLoS One. 2013 Jul 16;8(7):e68669.

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