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T5910047

Chemical Structure : T5910047

CAS No.: 941384-56-1

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T5910047 (T-5910047, T 5910047)

Catalog No.: PC-35815Not For Human Use, Lab Use Only.

T5910047 (T-5910047) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    T5910047 (T-5910047) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation.
    T5910047 inhibits SEB-induced inhibition of cytokine production in PBMCs with IC50 of 2-10 uM.
    T5910047 also inhibits SEA-induced pro-inflammatory cytokine production, shows no toxicity in primary cells up to 100 uM.

    Physicochemical Properties

    M.Wt 442.61
    Formula C18H26N4O3S3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-5-((3-(2-(4-methylpiperidin-1-yl)-2-(thiophen-2-yl)ethyl)ureido)methyl)thiophene-2-sulfonamide

    References

    1. Olson MA, et al. Sci Rep. 2015 Sep 18;5:14246.

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