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T6167923

Chemical Structure : T6167923

CAS No.: 2437475-16-4

T6167923 (T 6167923;T-6167923)

Catalog No.: PC-35814Not For Human Use, Lab Use Only.

T6167923 (T-6167923) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

T6167923 (T-6167923) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation; inhibits SEB-induced inhibition of cytokine production in PBMCs with IC50 of 2-10 uM, also inhibits SEA-induced pro-inflammatory cytokine production, shows no toxicity in primary cells up to 100 uM; specifically inhibits TIR domain-mediated dimerization of full-length MyD88 as well as the recombinant TIR domain protein; dose-dependent in vivo therapeutic efficacy against SEB intoxication.

Physicochemical Properties

M.Wt 458.389
Formula C17H20BrN3O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-4-((3-bromophenyl)sulfonyl)-N-(1-(thiophen-2-yl)ethyl)piperazine-1-carboxamide

References

1. Olson MA, et al. Sci Rep. 2015 Sep 18;5:14246.

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