T6167923 (T-6167923) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation.
T6167923 inhibits SEB-induced inhibition of cytokine production in PBMCs with IC50 of 2-10 uM, also inhibits SEA-induced pro-inflammatory cytokine production, shows no toxicity in primary cells up to 100 uM.
T6167923 specifically inhibits TIR domain-mediated dimerization of full-length MyD88 as well as the recombinant TIR domain protein.
T6167923 dose-dependent in vivo therapeutic efficacy against SEB intoxication.
