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Chemical Structure : TA-01
CAS No.: 1784751-18-3
Catalog No.: PC-42058Not For Human Use, Lab Use Only.
TA-01 is a potent inhibitor of Casein Kinase CK1ε, CK1δ and p38α with IC50 of 6.4, 6.8 and 6.7 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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TA-01 is a potent inhibitor of Casein Kinase CK1ε, CK1δ and p38α with IC50 of 6.4, 6.8 and 6.7 nM, respectively.
TA-01 inhibits the phosphorylation of proteins downstream of p38α MAPK such as MAPKAPK2 and HSP27 during cardiogenesis, and increases ATF-2 and MEF2C during cardiac differentiation.
| M.Wt | 351.3246 | |
| Formula | C20H12F3N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Pyridine, 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]- |
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1. Laco F, et al. J Mol Cell Cardiol. 2015 Mar;80:56-70.
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