TA-01 |CAS:1784751-18-3 Probechem Biochemicals

Chemical Structure : TA-01

CAS No.: 1784751-18-3

TA-01 (TA01;TA 01)

Catalog No.: PC-42058Not For Human Use, Lab Use Only.

TA-01 is a potent inhibitor of Casein Kinase CK1ε, CK1δ and p38α with IC50 of 6.4, 6.8 and 6.7 nM, respectively.

Packing	Price	Stock
5 mg	$118	In stock
10 mg	$178	In stock
25 mg	$298	In stock
50 mg	$488	In stock
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Biological Activity

TA-01 is a potent inhibitor of Casein Kinase CK1ε, CK1δ and p38α with IC50 of 6.4, 6.8 and 6.7 nM, respectively.
TA-01 inhibits the phosphorylation of proteins downstream of p38α MAPK such as MAPKAPK2 and HSP27 during cardiogenesis, and increases ATF-2 and MEF2C during cardiac differentiation.

Physicochemical Properties

M.Wt	351.3246
Formula	C20H12F3N3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyridine, 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-

References

1. Laco F, et al. J Mol Cell Cardiol. 2015 Mar;80:56-70.

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TA-01 (TA01;TA 01)

Biological Activity

Physicochemical Properties

References

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